SCMR-LAC

Prediction of All-Cause Mortality From Global Longitudinal Speckle Strain
Comparison With Ejection Fraction and Wall Motion Scoring

Tony Stanton, MBChB, PhD; Rodel Leano, BS and Thomas H. Marwick, MBBS, PhD
From the School of Medicine, University of Queensland, Brisbane, Australia.

Background— Although global left ventricular systolic function is an important determinant of mortality, standard measures such as ejection fraction (EF) and wall motion score index (WMSI) have important technical limitations. The aim of this study was to compare global longitudinal speckle strain (GLS), an automated technique for measurement of long-axis function, with EF and WMSI for the prediction of mortality.
Methods and Results— Of 546 consecutive individuals undergoing echocardiography for assessment of resting left ventricular function, 91 died over a period of 5.2±1.5 years. In addition to Simpson biplane EF, WMSI was determined by 2 experienced readers and GLS was calculated from 3 standard apical views using 2D speckle tracking. The incremental value of EF, WMSI, and GLS to significant clinical variables was assessed in nested Cox models. Clinical factors associated with outcome (model 2=20.2) were age (hazard ratio [HR], 1.46; P<0.01), p="0.01)," p="0.03)" 2="34.9,">35% and those with and without wall motion abnormalities. A GLS –12% was found to be equivalent to an EF 35% for the prediction of prognosis. Intraobserver and interobserver variations for EF and GLS were similar.
Conclusions— GLS is a superior predictor of outcome to either EF or WMSI and may become the optimal method for assessment of global left ventricular systolic function.

Key Words: echocardiography • ventricular function • strain • mortality

Circ Cardiovasc Imaging.2009; 2: 353-355 .